Strategy construction to minimize the limitation of respiratory viral vaccine development

Recent outbreak by the coronavirus SARS-CoV-2 is a major global public threat. Similarly, for several years other coronaviruses, RSV or Influenza viruses are also equally showing risk to worldwide population. Therefore, countries have been given tremendous efforts generate an effective vaccine against respiratory viral infections. It very important understand attributes of protective mucosal antiviral immune response development Characteristics system and evolution play role in protection infection. Memory CD8 T cell populations crucial making high levels gamma interferon tumour necrosis factor may be essential protection. Whereas developed vaccines infections continue fail effectively generating long-lived immunity. Hence, memory can elicit immunity, immunostimulatory adjuvants such as OX40, OX40L IL12 enhance cell. Viroporin on hand use candidate avoid mutation, result, present review work was constructed novel combination i.e., adjuvant with newly antigenic gene that fulfill limitation